Elon Musk just proved my point on SNL last night when he said people like him, people with Asperger's, see the world differently. Asperger's and a whole range of other "disorders" are actually evolution in the making. Humanity is on the precipice of achieving a new species that will have to learn to co-exist with Homo sapiens sapiens, if Hss doesn't mess it up first.
In Sing the Mice, I made a correlation between invasive weeds/non-native plants and genetic mutations becoming fixed in the population. If you noticed, the "aliens" did not care that Aline put great store into identifying which plants in her garden were "non-native" and which were native, they were only interested in the medicinal uses of the plants. And Keith compared the genetically mutated to invasive weeds that needed to be eradicated. From the alien's perspective on evolution, I conclude that all introductions that lead to genetic differences are part of evolution. If people introduce non-native species, or alter our genomes beneficially or irreparably, nature will have the dirty job of sorting it out with natural selection. And if we do it to ourselves, we may ultimately pay the price with extinction, and we will have deserved it. Therefore, there really is no such thing as a non-native species - there is only a challenge to the status quo.
Humans have amassed mutations that give them a competitive advantage to life in space, under micro-gravity conditions, and/or life under different planetary conditions. So, by necessity or choice, should the challenges of life in space or life on another planet present itself in our futures, those with the beneficial mutations will thrive. Therefore, these mutations should be preserved, not eradicated like invasive weeds.
Here are some examples of mutations, which under current Earth conditions might seem to be detrimental and selected against by nature, but under other conditions could confer survival advantages.
Connective Tissue Disorders (e.g. Ehlers Danlos, Scleroderma, Sjogren's, Marfan's). I will take the case of Ehlers Danlos, with which I am most familiar. Prevalence ~1/2500 people.
Under micro-gravity conditions (space) the blood vessels are more prone to atherosclerosis (hardened walls). People with Ehlers Danlos, under Earth gravity conditions, experience levels of inflammation due to mast cell activation up-regulation that can cause atherosclerosis, aneurysms, allergies, anaphylaxis, and arterial dissections. However, I hypothesize that under micro-gravity, people with Eherls Danlos will have less atherosclerosis than normal people, due to the leveling effect of micro-gravity on mast cell levels.
Hajime, F et.al. Mast Cell Promotes the Development of Intracranial Aneurysm Rupture. Stroke, October 2020, Vol. 51, N.11. DOI: https://doi.org/10.1161/STROKEAHA.120.030834
Mada, B. The pseudo-allergic/neurogenic route of mast cell activation via MRGPRX2.... Itch, April -June 2020, Vol. 5, Issue 2. pe32 DOI: 10.1097/itx.0000000000000032
In space, astronauts' bodies change to compensate for micro-gravity. When astronauts return to earth after living under micro-gravity conditions, they experience POTS (Postural Orthostatic Tachychardia Syndrome), or changes in blood flow/volume and heart rate when changing position (e.g. sitting to standing).
Mathias, Tamara. Research in Astronauts Sheds Light on Rare Fainting Disorder, Reuters, August 13, 2019. https://www.reuters.com/article/us-health-heart-fainting/research-in-astronauts-sheds-light-on-rare-fainting-disorder-idUSKCN1V320F
POTS resolves and improves when: lying down, increasing fluid intake and salt consumption to increase blood volume, and wearing a compression garment (like a proprioception suit) to keep blood from pooling in extremities. People with Ehlers Danlos, however, experience POTS under Earth gravity, due to an immune response (mast cell activation again) that causes POTS and many other symptoms.
Under micro-gravity, brains move up in the skull, causing problems for astronauts. People with Ehlers Danlos can have brains that sit lower within the skull, and sometimes larger skulls. The brain resting lower can causing problems if it puts pressure on the brain stem. There can also be problems with a Chiari malformation. I suspect people with Ehlers Danlos may experience normalized brain position within the skull under micro-gravity conditions.
"Marrow cells obtained from rats flown in space showed decreased responses to granulocyte-monocyte colony-stimulating cytokines. Rat monocyte-macrophages also showed a reduced spreading, in vitro, and their differentiation was inhibited." William R. Beisel, Gravity, Effect of Space Flight on Immunity, in Encyclopedia of Immunology (Second Edition), 1998. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/granulocytosis
Space is an immuno-depressant. So, since stimulating cytokines and granulocytes are up-regulated on Earth in some people with Ehlers Danlos who also have Mast Cell Activating up-regulation (the disorders are often concomitant, and I will address that later), these people already have a compensatory immune mechanism built in to withstand the down-regulating effects of space. This inborn up-regulation under Earth gravity may well mean that they level out or normalize in space, thus experiencing none of the inflammatory issues involved with up-regulation they experience at Earth gravity (mast cell over-activation causes aneurysms, blood vessel wall weakness and damage, and POTS).
And finally, what does this have to do with Elon Musk? I don't think it's a leap to say Elon Musk is intelligent; he has just announced he has Asperger's. It is my theory, that mast cell over-activation can disrupt neuronal migration during embryogenesis in genetically prone individuals (people with connective tissue disorder genes), causing autism spectrum disorders. Since Ehlers Danlos, for instance, is as common as 1 in 2500, and Mast Cell Activation Disorder is currently recognized at 1 in 10,000 (likely much higher), I can only conclude that the resulting disruption in neuronal migration, whether from exposure to chemicals, viruses, or vaccines is part of human evolution. There are times when the differences in neuronal migration confer advantage, and times when they do not. I hesitate to call any of these issues disordered. Ehlers Danlos, Mast Cell Activation Disorders, and Autism Spectrum Disorders are correlated (it is not uncommon to find them together and in families). Either way, I believe these differences are necessary, as they may be our only chance to survive beyond Earth, to evolve into a new species.
Theoharis, CT et.al. Mast Cell Activation and Autism. Biochim Biophys Acta, 2012 Jan;1822(1):34-41. doi: 10.1016/j.bbadis.2010.12.017. Epub 2010 Dec 28. https://pubmed.ncbi.nlm.nih.gov/21193035/
Mast cell activation and autism
The below articles are evidence of why people with Mast Cell Activation Disorders, or disorders that pre-dispose them to POTS, should be pre-treated with Mast Cell Inhibitors before and after vaccination. Vaccine induced POTS is well referenced in the literature. Also, since mast cell activation/cytokine storm is a reaction in a few with COVID-19, it follows that the anaphylactic reactions seen in the vaccine campaigns are probably caused by the same mechanism. People with Mast Cell Activation disorders are probably both, more likely to have a severe reaction to infection and more likely to have an anaphylactic reaction to vaccination. Why this hasn't been elucidated, I don't know. It seems obvious to me. If this genotype is being wiped out by the virus and the vaccine, mankind may be doomed to life on Earth.
Conti, P. et.al. Mast cell activated by SARS-CoV2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19. J Biol Regul Homeost Agents. 2020 Sep-Oct: 34(5):1629-1632. DOI: 10.23812/20-2EDIT
Lucija Tomljenovic, PhD, Serena Colafrancesco, MD, Carlo Perricone, MD, ... Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”: Case Report and Literature Review
First Published March 18, 2014 Case Report
Other References:
Milewicz, D et.al. Vascular Ehlers-Danlos Syndrome: Exploring the Role of Inflammation in Arterial Disease. Circulation: Cardiovascular Genetics, Vol. 7, No. 1, February 2014. DOI: https://doi.org/10.1161/CIRCGENETICS.114.000504
These are only two of the genes involved in Mast Cell Activation, that I think are relevant to what I'm discussing above: KIT mast/stem cell growth factor receptor Chromosome 4q12.21, L1CAM X Chromosome . There are a number of other immune system genes (chromosome 6 MHC genes, and JAK2 gene); there are Zinc Finger Protein genes and Solute Carrier genes that are also relevant, but I can't untangle them. A competent understanding of extracellular matrix, connective tissue disorders, and neuronal migration is helpful.
See Gschwandtner, Proteome Analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells DOI: 10.1111/all.12919
Shieh, G ... Mutation in the sixth immunoglobulin domain of L1CAM is associated with migrational brain anomalies, Neurology Genetics, 2015, Dec: 1(4):e34 PMC 4811382.
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